Using a new technique called cryo-electron tomography, two research teams at Baylor College of Medicine have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.To s
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Mutation Disrupts Architecture Of Rod Sensory Cilium
Posted by Praveen (#2) 4181 days ago (Editorial)Epigenetic Study Suggests Immune System Could Play A Central Role In AMD
Posted by Praveen (#2) 4091 days ago (Editorial)
Changes in how genes in the immune system function may result in age-related macular degeneration (AMD), the leading cause of visual impairment in older adults, based on preliminary research conducted by National Institutes of Health (NIH) investigators. The study identified decreased levels of DNA methylation, a chemical reaction that switches off genes, on the interleukin-17 receptor C gene (I
Insulin plus Growth Factor Inhibitor Limits Vision Damage In Diabetic Mice
Posted by Praveen (#2) 4081 days ago (Editorial)
A new therapeutic approach to diabetes that combines insulin and an inhibitor of the epidermal growth factor (EGF) betacellulin could limit the progression of diabetic macular edema (DME), Cleveland Clinic researcher Bela Anand-Apte, MD, PhD, said at the American Society for Cell Biology Annual Meeting, on Dec. 17 in San Francisco. The study, conducted with insulin-dependent diabetic mice, showe
App Expands Screening for Diabetic Retinopathy
Posted by Praveen (#2) 4033 days ago (Editorial)
An app-based telemedicine program significantly increases screening for diabetic retinopathy at community health clinics, according to a multicenter randomized controlled trial. This is a more convenient form of screening than traditional surveillance by an ophthalmologist, and it is "done right in the clinic," Steven Mansberger, MD, director of glaucoma services at the Devers Eye Institute in Po
First Drug to Help Melanoma of the Eye
Posted by Praveen (#2) 4026 days ago (Editorial)
AstraZeneca's experimental drug, selumetinib, is the first targeted medication to show a significant clinical benefit for patients with melanoma of the eye (metastatic uveal melanoma), researchers from the Memorial Sloan-Kettering Cancer Center explained at the 49th annual meeting of the American Society of Clinical Oncology (ASCO), in Chicago, Illinois.
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Age-Related Macular Degeneration and Genes: Scientists Identify 7 New Genetic Risk Factors
Posted by Praveen (#2) 4013 days ago (Editorial)
New research from government scientists paints a clearer picture of how genetics may play a role in age-related macular degeneration, or AMD, the leading cause of blindness in people age 60 and older. Researchers have identified seven places on the human genome that seem to be linked with the vision loss condition, adding to the 12 that had been identified in previous research. The study is publi
Prevent Blindness America Provides Tips and Tools to Promote Children’s Vision and Eye Health as New School Year Begins
Posted by Praveen (#2) 3979 days ago (Editorial)
As many children begin to head back to school after the summer break, Prevent Blindness America hopes to help educate parents and educators on the importance of children’s vision. According to the recent “Cost of Vision Problems: The Economic Burden of Vision Loss and Eye Disorders in the United States” study from Prevent Blindness America, vision disorders in children ages 0-17 cost Americans mo
Gene Regulator Is Key to Healthy Retinal Development and Good Vision in Adulthood
Posted by Praveen (#2) 3962 days ago (Editorial)
Scientists are developing a clearer picture of how visual systems develop in mammals. The findings offer important clues to the origin of retinal disorders later in life. in research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the devel