An intermediate cumulative dose of IV methylprednisolone may be the best approach for active Graves' orbitopathy, a new study from Europe indicates. Orbitopathy affects about 50% of patients with Graves' disease, but only 3% to 5% have severe forms of the disease. Glucocorticoids are the first line treatment, but the optimal regimen remains to be defined.To see more details visit, www.medscape.com